Manhasset, NY (Vocus) 11 October 2010

Infants

cardiopulmonary bypass spend less time on a ventilator when they receive a supplement of the thyroid gland, according to a new study published in the journal Circulation. Scientists at the Institute for Medical Research were porcelain, the pioneers of research into the relationship between thyroid hormones and cardiovascular disease. The Feinstein Institute? S Sara Danzi, PhD, in collaboration with doctors across the country on the idea that can test T3 supplementation in infants and children during the operation have a protective effect and lead to less time to intubation.

He was known for research that Feinstein lower T3 levels in chronic and acute injuries. T3 has a profound impact on virtually all tissues and organ systems, including control of the cardiovascular system. Be as thorough T3 particularly important in heart failure. Scientists have to undergo preventive intervention in adults, heart bypass surgery, and it was tested to improve cardiac index.

infants are much more susceptible to problems during the motion so that the scientists a multicenter, placebo-controlled disadvantages randomized, designed, whether spent infants and young children a few days, wear a respirator if she were an intravenous dose of thyroid hormone given. Michael A. Portman, MD, Director, Pediatric Surgery, Cardiovascular Research, Seattle Children? S Hospital, was lead author of the study. The study included 193 children under two years. The children were matched by age disparity, and then randomized into a treatment group or control. After surgery, the researchers examined how long it was before their breathing tubes were removed.

There was a significant advantage for the most vulnerable children: those with less than five months. The average time to extubation was 98 hours in the placebo group compared with 55 hours in those treated with T3 before surgery. Time to extubation is a measure that proposes that children could better and without a machine to help them breathe.

T3 supplementation is no difference for older children who are healthier and better on the heels of the surgery, says Dr. Danzi. â? Maybe one day it will undergo a standard treatment for infants, the bypass operation, â? She said.

About the Feinstein Institute for Medical Research

headquarters in Manhasset, NY, Institute for Medical Research Feinstein (www.feinsteininstitute.org) hosts the international scientific leaders in cancer, leukemia, lymphoma, Parkinson’s, Alzheimer’s disease? ? S disease, psychiatric disorders, rheumatoid arthritis, lupus, sepsis, intestinal diseases, inflammation, diabetes, human genetics, neuroimmunology, and medicinal chemistry. Feinstein researchers develop new drugs and therapeutic targets, and producing results where science meets the patient, per year enroll approximately 10,000 patients in clinical research programs.

Contact: Jamie Talan

science writer in residence

Phone: 516-562-1232

E-mail: jtalan (at) NHHS (dot) edu

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